At 12:15PM Big Sister took to the air over CBS starring the just-heard Alice Frost as Ruth Evans.

Ruth centered her life around her sister Sue and their crippled brother Neddie. When Sue married reporter Jerry Miller, Ruth was able to give her full attention to the care of little Ned. Then, unexpectedly, Ruth fell in love with Neddie’s new doctor, John Wayne, played first by Martin Gabel and later by Staats Cotsworth.