Inhalational anthrax is an acute infectious disease caused by exposure of the lungs to B. anthracis spores. Alveolar macrophages engulf spores causing them to germinate to the vegetative form of B. anthracis, which secretes edema toxin (ET)and

NMR-spektroskopische und röntgenkristallographische Untersuchungen von ein- und zweikernigen Palladium(II)-Kohlenhydratkomplexen

Apr 3rd, 2008

Kohlenhydrate gehören zu den Biomolekülen mit dem mengenmäßig größten Anteil in der Natur, jedoch wurden sie lange Zeit fast ausschließlich als Energiespeicher, Stütz- und Gerüstsubstanzen betrachtet. Die in den letzten Jahren stetig wachsenden

Investigations on Flagellar Biogenesis, Motility and Signal Transduction of Halobacterium salinarum

Mar 17th, 2008

Persistente Radikalanionen mit ungewöhnlichen Eigenschaften auf der Basis von Carbonsäureimiden

Feb 28th, 2008

Functional Architecture of RNA polymerase I

Feb 27th, 2008

Synthesis of ribosomal RNA by RNA polymerase (Pol) I is the first step in ribosome biogenesis and a regulatory switch in eukaryotic cell growth. In this thesis a reproducible large-scale purification protocol for Pol I from S. cerevisiae could

Molecular analyses of resistance and sensitivity mechanisms to anti-EGFR directed tumor therapy

Feb 25th, 2008

This study characterized a panel of NSCLC cell lines as well as a stably transfected cell model expressing wild-type and mutated EGFR variants in terms of response to the EGFR-targeting drugs, gefitinib and cetuximab. The examinations support t

Klonierung, rekombinante Expression und erste Charakterisierung des humanen hodenspezifischen Serinprotease-ähnlichen Proteins T-GPI-SP1

Feb 20th, 2008

Neue Wege zur Synthese der marinen Naturstoffe Oroidin, Cyclooroidin und verwandter Moleküle

Feb 19th, 2008

Structural Characterization of the DNA Repair Protein Complex SbcC-SbcD of Thermotoga maritima

Feb 14th, 2008

DNA damage poses a considerable threat to genomic integrity and cell survival. One of the most harmful forms of DNA damage are double-strand breaks that arise spontaneously during regular DNA processing like replication or meiosis. In addition,

The Structure of RseB, a Sensor for Periplasmic Stress in Escherichia coli

Feb 7th, 2008

RseB from Escherichia coli has been crystallized and crystal structures were determined at 2.4 Å and at 2.8 Å resolution. The structure of cytoplasmic expressed RseB revealed that it consists of two domains; an N-terminal large and a C-terminal

Structural characterisation of transcription and replication through cisplatin lesioned DNA

Feb 7th, 2008

Replication of the genome is strongly inhibited when high fidelity DNA polymerases encounter unrepaired DNA lesions, which can not be processed. The highly stringent active sites of these polymerases are unable to accommodate damaged bases and

Hochfunktionalisierte Magnesiumorganyle zur Synthese von funktionalisierten Benzyl-, Ferrocen- und Indolderivaten

Jan 30th, 2008

Influence of Ginkgo biloba extract EGb 761 on signaling pathways in endothelial cells

Jan 25th, 2008

Polyfunctionalizations of N-Heterocycles via Chemo- and Regioselective Metalations

Jan 10th, 2008

Untersuchung von Interaktionen intrazellulärer Signalkaskaden

Dec 21st, 2007

Entwicklung robuster Quantengatter auf infrarot-aktiven Qubits in MnBr(CO)5

Dec 20th, 2007

Die vorliegende Arbeit behandelt die experimentell umsetzbare Implementierung von Molekularem Quantencomputing, wie es in der Arbeitsgruppe um R. de Vivie-Riedle entwickelt wurde. Dieses Konzept beruht auf Laser-vermittelter Kontrolle intramole

Application of Many-Body Perturbation Theory to the Description of Correlated Metals

Dec 20th, 2007

An efficient computational LSDA+DMFT toolbox for the description of correlated materials has been established. The method developed in this work provides an appropriate description of 3d-transition metal correlated bulk systems, concerning thei