The plague led to a drastic reduction in population, labor shortages, and social upheaval. Entire villages and towns were depopulated, and some regions saw a collapse of agricultural and economic systems. People in the 14th century had little understanding of the causes of the plague, and various responses were attempted, including quarantine measures, flagellant movements, and persecution of minority groups, such as Jews and lepers. None of these measures were effective in halting the spread of the disease. This disruption of the social and economic order created a climate of fear, uncertainty, and hardship. In times of crisis, people often sought explanations and scapegoats for their suffering, which could include the persecution of perceived outsiders and those accused of witchcraft.

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Sources: 

Caliban and the Witch by Silvia Federici

Witchcraft, Lycanthropy, Drugs and Disease by Homayun Sidky

Discipline and Punish by Michel Foucault

Credits:

Script by Sovereign Syre

Hosted by Sovereign Syre & Ela Darling

Produced by Joshua Anderson