Between 1999 and 2015, roughly 300,000 people in the United States died from opioid overdoses. And of the five states with the highest rates of drug overdose deaths in 2016, four were in Appalachia. In this week's episode of Inside Appalachia, we'll hear a special report from The Uncertain Hour , a podcast from American Public Media's Marketplace. Their investigation, which first aired in December, centered on a lesser-known but significant aspect of the opioid crisis: how Purdue Pharma marketed OxyContin, its highly addictive pain medication.