Featuring articles on preventing cardiovascular disease in HIV infection, the effect of hemodiafiltration or hemodialysis on mortality in kidney failure, a new KRAS G12C inhibitor in solid tumors, and on partial artemisinin resistance in malaria parasites; a review article on protein-losing enteropathy; a case report of a girl with abdominal pain and an ovarian mass; and Perspective articles on the Supreme Court and diversity in medicine, on outbreaks in U.S. migrant detention centers, on turning CMS into a health technology assessment organization, and on the clinic that cried safe.