Featuring articles on on enzalutamide and leuprolide in prostate cancer, optical coherence tomography (OCT)–guided versus angiography-guided PCI, vancomycin and cefazolin prophylaxis in arthroplasty, and on OCT and eye care; a review article on the syndrome of inappropriate antidiuresis; a case report of a woman with recurrent hemorrhagic pericardial effusion; and Perspective articles on Yellow Jack’s potential return to the American South; on wedding websites, free speech, and adverse drug effects; and on a chance to modernize health care behind bars.