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Novel Targets
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Episodes of Novel Targets
Mark All
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The award of this year's Nobel prize in physiology or medicine to Dr Jim Allison and Dr Tasuku Honjo is a defining moment for cancer research that we want to recognize.You'll hear from Dr Allison on the very day he heard the announcement. We
In this episode we continue our journey looking at the innate immune system and focus on some important immune cells called natural killer (NK) cells and their potential in cancer immunotherapy.You'll hear from both academic and industry expe
In this episode we explore the innate immune system and find out what it is, what it does and why it matters in both health and disease. You'll hear various perspectives from both academic and industry experts who are active in research in t
In this episode we take a look a look at how cytokines can be employed to modulate the tumour microenvironment in favourable ways. You'll hear various perspectives from numerous academic and industry experts who are active in research in thi
Welcome back to Season 4! In this latest episode, we take a look at data from immunotherapy clinical trials from several different angles and investigate the challenges associated presented by different combination partners, control arms, patie
In this episode we're exploring some controversial issues in cancer research including real world versus clinical trial experience and immune related toxicities, as well as highlighting strength and weaknesses around some encouraging new data w
In this latest episode we're exploring an up and coming area of cancer research, namely therapeutic cancer vaccines.If we want to jumpstart the immune system in cold/non-inflamed/desert tumours, then we need to find ways to attract more T cel
In this episode we're exploring ways to jumpstart the immune system so that subsequent therapies can be more effective, especially in cold non-inflamed tumours.It is becoming increasingly clear that people with pre-existing immunity respond b
In the latest episode of Novel Targets, we take a look at new developments in breast cancer.Breast cancer can be organised into several distinct subsets for the purposes of treatment:- Hormone sensitive disease (HR+) - HER2+ - Triple neg
Welcome back to Season 3. In this episode we're tackling one of the hottest topics in cancer research, why do cancer immunotherapies work in some people, but not in others? Why do they stop working? If we want to obtain long durable responses
This episode was recorded at the 2016 annual meeting of the American Society of Hematology (ASH) in San Diego.You’ll hear excerpts from interviews with leading experts, who discuss some of the latest clinical data and controversies in liquid
In this episode, listeners receive a ticket to ride the Copenhagen Metro to the 2016 Congress of ESMO, the European Society for Medical Oncology.Along the way we hear from experts about targeting ovarian cancer and some of the latest data on
In this episode, you’ll hear from two pioneers at the forefront of developing safe and effective Chimeric Antigen Receptor (CAR) T cell therapy.Dr Michael Jensen is Director of the Ben Towne Center for Childhood Cancer Research at Seattle Chi
This episode discusses some of the cancer immunotherapy data presented at the 2016 annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago. It’s the largest cancer meeting in the world, with over 35,000 attendees.You’ll
In this episode you’ll hear from Dr Bernie Fox (pictured), Dr Ina Rhee and Emeritus Professor Kees Melief. We talked to all three scientists at the 2016 annual meeting of the American Association for Cancer Research (AACR) in New Orleans.One
Season 2 of Novel Targets kicks off with an episode on the Cancer Immunity Cycle. Back in 2013, Genentech scientists Drs Daniel Chen and Ira Mellman (pictured) published a paper in the journal Immunity: “Oncology meets Immunology: the cancer-
Episode 10 is on New Horizons in Hematology and features excerpts from interviews recorded at last December's annual meeting of the American Society of Hematology (ASH).In Orlando, we spoke to experts about some of the latest data in AML, Mul
In this episode we're looking at how to make therapies that target our immune system more effective.Could it be as simple as changing the composition of the bacteria in the gut, the intestinal microbiome that contains a gazillion bugs?Dr To
A pioneer is someone who helps develop something new and prepares the way for others to follow.We want to harness our immune system to fight and cure cancer. In this episode you’ll hear from two (of the many) pioneers in the field of cancer
More than 19,000 people from over 100 countries travelled to Vienna at the end of September 2015 for the European Cancer Congress.Cancer immunotherapy was the hot topic of the meeting. There were several late-breaking abstracts for clinical t
Checkpoint inhibitors act to “release the break” cancer puts on the immune system. There are also immune agonists that are stimulatory in effect. They help to “step on the gas” and make the immune system more effective.In this episode you’ll
There are multiple ways to use the body's immune system to fight cancer. One novel approach is through Adoptive Cell Therapy - you take T lymphocytes or "T cells" out of a patient - these are the warriors of the immune system - manipulate th
Checkpoint inhibitors do not work well in cancers where there is no underlying immune response. One example of such a non-inflamed tumor is prostate cancer. So a key question is how do we convert a non-inflamed tumor (few T Cells present) i
Lung cancer is the No 1 cause of cancer related death in the United States.Which is why the whole of this episode is devoted to the latest lung cancer data presented at the 2015 annual meeting of the American Society of Clinical Oncology (ASC
Biomarkers may help us predict who will respond to checkpoint inhibitors that target the PD1 PDL1 signaling pathway.They may also help us increase the number of patients that respond by understanding how to overcome suppression in the tumor m
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