Dr. John Fleetham chats with Dr. Gozal on his article, "Senolytic-facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea."

Effectiveness of Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Mar 28th, 2024 20m 49s

Dr. John Fleetham chats with Dr. Bijan Teja and Dr. Nicholas Bosch about their article, "Effectiveness of Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomiz

Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation and Inhaled Microplastics and Airway Development: Concerning Evidence from Organoids

Feb 21st, 2024 25m 59s

Dr. John Fleetham chats with Dr. Barbro N Melgert and Dr. Chris Carlsten about their articles, "Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation" and "Inhaled Microplastics and Airway Development: Concerning Eviden

A New Global Definition of Acute Respiratory Distress Syndrome

Jan 17th, 2024 33m 5s

Dr. Michael Lanspa chats with Dr. Michael Matthay about his article, "A New Global Definition of Acute Respiratory Distress Syndrome."

External Control Arms in Idiopathic Pulmonary Fibrosis Using Clinical Trial and Real-World Data Sources and The Added Power of Synthetic Control Groups: Challenging Conventional Wisdom and Trial Design in Idiopathic Pulmonary Fibrosis Research

Jan 16th, 2024 32m 50s

Dr. Mohleen Kang chats with Dr. Aparna Swaminathan and Dr. Timothy Dempsey about their articles, "External Control Arms in Idiopathic Pulmonary Fibrosis Using Clinical Trial and Real-World Data Sources” and “The Added Power of Synthetic Control

The Combination of Aroxybutynin and Atomoxetine in the Treatment of Obstructive Sleep Apnea (MARIPOSA): A Randomized Controlled Trial and Pharmacologic Therapy for Obstructive Sleep Apnea: Are We Seeing Some Light at the End of the Tunnel?

Dec 8th, 2023 22m 43s

Dr. John Fleetham chats with Dr. Paula K. Schweitzer and Dr. Najib Ayas about their articles, "The Combination of Aroxybutynin and Atomoxetine in the Treatment of Obstructive Sleep Apnea (MARIPOSA): A Randomized Controlled Trial" and "Pharmacol

FEV1/FVC Severity Stages for Chronic Obstructive Pulmonary Disease

Oct 5th, 2023 16m 21s

Dr. John Fleetham chats with Dr. Surya Bhatt about his article, “FEV1/FVC Severity Stages for Chronic Obstructive Pulmonary Disease.”

Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial

Sep 28th, 2023 17m 14s

Dr Michael Lanspa chats with Dr. Imeen van der Wal and Dr. Chloe Grim on their article, "Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial."

Pulse Wave Amplitude Drops Index: A Biomarker of Cardiovascular Risk in Obstructive Sleep Apnea

Jul 20th, 2023 20m 38s

Dr. John Fleetham chats with Dr. Raphael Heinzer about his article, "Pulse Wave Amplitude Drops Index: A Biomarker of Cardiovascular Risk in Obstructive Sleep Apnea."

Individualized Treatment Effects of Bougie vs Stylet for Tracheal Intubation in Critical Illness

Jun 22nd, 2023 25m 9s

Dr. Michael Lanspa chats with Dr. Kevin Seitz and Dr. Matthew Churpek about their article, "Individualized Treatment Effects of Bougie vs Stylet for Tracheal Intubation in Critical Illness."

Effectiveness of Bedaquiline Use Beyond Six Months in Patients with Multidrug-Resistant Tuberculosis

May 11th, 2023 22m 10s

Dr. John Fleetham chats with Dr. Molly Franke and Dr. James Brust about their articles, "Effectiveness of Bedaquiline Use Beyond Six Months in Patients with Multidrug-Resistant Tuberculosis" and “Weighting” the evidence: How much bedaquiline is

Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III)

Mar 23rd, 2023 33m 19s

Dr. Michael Lanspa chats with Dr. Yahya Shehabi about his article, "Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III).

Tuberculosis Diagnoses Following Wildfire Smoke Exposure in California

Mar 2nd, 2023 17m 48s

Dr. John Fleetham chats with Dr. Joseph Lewnard and Dr. Will Checkley about their articles, "Tuberculosis Diagnoses Following Wildfire Smoke Exposure in California" and "Tuberculosis, Wildfires, and Case-crossover Studies: An Epidemiological Tr

Tuberculosis Diagnoses Following Wildfire Smoke Exposure in California

Mar 2nd, 2023 17m 48s

Assessing Pretomanid for Tuberculosis (APT), a Randomized Phase 2 Trial of Pretomanid-containing Regimens for Drug-sensitive TB: 12-Week Results

Dec 15th, 2022 14m 59s

Paper discussed in today's episode:Assessing Pretomanid for Tuberculosis (APT), a Randomized Phase 2 Trial of Pretomanid-containing Regimens for Drug-sensitive TB: 12-Week Results

Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness

Dec 1st, 2022 24m 3s

Papers discussed in today's episode:Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive SleepinessContinuous Positive Airway Pressure and Cardiovascu

High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial

Nov 24th, 2022 28m 24s

Paper discussed in today's episode:High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial

Autoimmune Pulmonary Alveolar Proteinosis

Sep 1st, 2022 21m 47s

Article discussed in this episode:Autoimmune Pulmonary Alveolar Proteinosis

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis

Aug 18th, 2022 27m 31s

Article discussed in this episode:Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis

Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities

Aug 11th, 2022 25m 55s

Article discussed in this episode:Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities

A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea

Jun 9th, 2022 23m 58s

Articles discussed in this episode:“A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea"“Drug Therapy for Obstructive Sleep Apnea: Are We There Yet?”

Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions

Apr 21st, 2022 17m 26s

Article discussed in this episode:Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions

Effect of Weight Loss and CPAP on OSA and Metabolic Profile Stratified by Craniofacial Phenotype

Mar 17th, 2022 20m 5s

Article discussed in this episode:Effect of Weight Loss and CPAP on OSA and Metabolic Profile Stratified by Craniofacial Phenotype: A Randomized Clinical Trial

Using Isoniazid More Safely and More Effectively in Tuberculosis Treatment

Feb 22nd, 2022 34m 39s

Articles discussed in today's episode:A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis TreatmentA Semimechanistic Model of the Bactericidal Activity of High-Dose Isoniazid against Multidrug-