The Winchesters are in a tough spot this week in Season 1, Episode 21, "Salvation." Meg's killing John's friends in order to get him to hand over the Colt, which Sam and Dean need in order to kill the Yellow-Eyed Demon, who's planning to attack a family in Salvation, Iowa. The episode ends with John getting captured by Meg and her demon brother and Sam trying to run into a burning building to get revenge on the YED. 

Dean does the Plot Recap and the Best Song (of the Episode AND the Series), Amanda does the Commentary, in which she talks about why "Carry On Wayward Son" has been her favorite song since she was 12, and Sammy helps Dean explain how Plushies Make Everything Better. 

• "Salvation" on Supernatural Wiki
• Pastor Jim Murphy on Supernatural Wiki
• Meg's tiny throat-slitting blade
• Sebastian Spence on IMDB