Iceland, an island nation of about 400,000 people, has seen fewer than 2,500 COVID-19 cases and only 10 deaths. Dr. Thorolfur Gudnason, Iceland’s chief epidemiologist, talks with Dr. Josh Sharfstein about how the country’s pandemic strategy meant they never had to close schools or restaurants, and how its research with genomic sequencing helped shed light on COVID-19 transmission and immunity. Gudnason also talks about the public’s response, how the country’s vital tourism industry has been affected, and his outlook on the next year.