Featuring articles on dexamethasone for TB meningitis in HIV-positive adults, the timing of complete revascularization after myocardial infarction, catheter ablation for advanced heart failure and AFib, ceftobiprole for Staph. aureus bacteremia, and on AlphaFold being recognized through a Lasker Award; a review article on Shiga toxin–producing E. coli and the hemolytic–uremic syndrome; a case report of a man with involuntary movements and unresponsiveness; and Perspective articles on whether pandemics ever end, on the new over-the-counter oral contraceptive pill, and on a reason to retire.